Journal of Investigative Dermatology (1974) 63, 142–146; doi:10.1111/1523-1747.ep12678272
MAMMOGENESIS IN TRANSSEXUALSNorman Orentreich and Nancy P Durr
Abstract
Photographs of modest to significant breast development in male transsexuals illustrate the range of male mammary tissue response, not strictly dose related, to hormonal feminization by exogenous estrogens and progestins, alone or in conjunction with castration. The histology of male mammary tissue is characterized in gynecomastia of varied etiology and in response to estrogen administration, with particular reference to lobule and aciniformation. Breast cancer is discussed in relation to both therapeutic and transsexual hormonal feminization of men. It does not appear that estrogens induce breast cancer in men.
